Neurosciences
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Sarcoidosis is a multisystem inflammatory disease of unknown etiology. Isolated neurosarcoidosis without signs of systemic involvement has rarely been reported in the literature. We report a case of isolated neurosarcoidosis that presented with psychiatric symptoms and headache. ⋯ Further research did not reveal any evidence of systemic disease. The patient was treated with corticosteroids and responded well to medical therapy. The diagnosis of isolated neurosarcoidosis is a challenge and may require histological examination.
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Review Meta Analysis
Induced hypothermia to treat neonatal hypoxic-ischemic encephalopathy. Review of literature with meta-analysis and development of national protocol.
The efficacy of induced hypothermia to treat hypoxic-ischemic encephalopathy (HIE) in term infants has been evaluated in 6 multicenter randomized controlled trials. Meta-analysis of these trials shows that hypothermia in the first 6 hours after moderately severe HIE reduced the risk rate of death or neurological impairment at 18 months of age; risk ratio (RR): 0.81 (95% confidence interval [CI]: 0.71 to 0.93, p=0.002); risk difference -0.11 (95% CI: -0.18 to -0.04), with a number needed to treat of 9 (95% CI: 5-25). ⋯ We developed a national protocol using a simplified method of cooling. This protocol will hopefully lead to a widespread implementation of induced hypothermia in different settings within Saudi Arabia.