Rev Neurol France
-
Review
[Apathy an neurodegenerative diseases: pathophysiology, diagnostic evaluation, and treatment].
Apathy is usually defined as a lack of motivation leading to reduced interest and participation in various activities. From a pathophysiological viewpoint, the most common cause of apathy is dysfunction of the frontal lobes, following either direct lesion of the frontal cortex or damage to regions tightly connected to the latter (such as the basal ganglia). ⋯ The methods for detecting apathy and assessing its severity are various, the main difficulty being to disentangle apathy and depression. The treatment of apathy per se remains anecdotal and, to date, little research into the efficacy of medication therapy has been performed.
-
Case Reports
[Ischemic stroke revealed by a thunderclap headache: contribution of diffusion-weighted mri sequences].
Sub-arachnoid hemorrhage, cerebral venous thrombosis and cerebral reversible angiopathies are the main causes of secondary thunderclap headache. Ischemic stroke is rarely revealed by thunderclap headache. ⋯ Ischemic stroke is a rare cause of thunderclap headache but practitioners should bear in mind this etiology when the diagnostic work-up is negative. Diffusion-weighted sequences of the brain MRI can provide the diagnosis.