J Rheumatol
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Comparative Study
Salicylate-induced gastrointestinal bleeding: comparison between soluble buffered, enteric-coated, and intravenous administration.
Serum salicylate levels and blood loss in stools were compared in 94 patients after intake of various forms of acetylsalicylate. Four different oral soluble forms, an enteric-coated variety and an intravenous form were evaluated. Analysis of the results of blood loss measurement in stools showed that salicylate users could be divided into "bleeders" and "non-bleeders". ⋯ Only after administration of enteric-coated or intravenous forms of salicylates was a relationship between serum salicylate level and blood loss in stools observed in "bleeders". This suggests a similar mode of action of both these preparations on gastric mucosa. We conclude that enteric-coated forms of salicylates cause gastrointestinal bleeding by a systemic action on gastric mucosa.
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Case Reports
Infectious parotitis in Sjögren's syndrome: a case report and review of the literature.
Infectious parotitis as a complication of the sicca syndrome has rarely been reported. A patient with bilateral parotitis due to H. influenza in reported and the literature regarding this rare complication of the sicca syndrome is reviewed. The host defense mechanisms which ordinarily protect normal individuals or patients with Sjögren's syndrome against purulent parotitis are discussed.