World J Gastroentero
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World J Gastroentero · Feb 2002
Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture.
To investigate the role of cytokine gene expression in organ damage at different tissue sites during sepsis. ⋯ The inflammatory response in the liver and lungs was different during sepsis. At the early stage of sepsis, pro-inflammatory reaction dominates both in the liver and lungs. But at the later stage of sepsis, induction of compensatory anti-inflammatory response was seen in the liver but not in the lungs. This difference in situ activity may contribute to the different vulnerability of organ damage during sepsis. The strategy of systemic administration of anti-inflammatory drugs to sepsis should be reconsidered.