Arch Ophthalmol Chic
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Arch Ophthalmol Chic · Mar 1980
Randomized Controlled Trial Comparative Study Clinical TrialLack of side effects from topically administered 10% phenylephrine eyedrops. A controlled study.
A prospective double-blind study was designed to determine the systemic hypertensive effects of topically administered 10% aqueous buffered phenylephrine hydrochloride vs topically administered 1% aqueous tropicamide, a belladonna alkaloid devoid of vasopressor effect. One hundred persons received phenylephrine, while 50 persons received tropicamide. ⋯ Mean blood pressure and pulse rate dropped from baseline values in both groups at 5, 15, and 30 minutes after drug administration. There was no statistically significant difference between the experimental and control groups with respect to drug effect on either blood pressure or pulse rate throughout the study.