Scandinavian journal of rheumatology. Supplement
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Scand. J. Rheumatol. Suppl.
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Scand. J. Rheumatol. Suppl. · Jan 2000
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEfficacy and tolerability of tropisetron in primary fibromyalgia--a highly selective and competitive 5-HT3 receptor antagonist. German Fibromyalgia Study Group.
Based on a potential role for serotonin receptors in fibromyalgia, we investigated the efficacy and tolerability of treatment with tropisetron, a highly selective, competitive inhibitor of the 5-HT3 receptor. ⋯ This study demonstrates the efficacy of short-term treatment with 5 mg tropisetron once daily in primary fibromyalgia. Treatment was well tolerated and prolonged clinical benefits were seen.