Resp Res
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Multicenter Study Clinical Trial Observational Study
Metformin use and respiratory outcomes in asthma-COPD overlap.
Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored. ⋯ Metformin use was associated with fewer respiratory exacerbations and improved quality of life among individuals with ACO but not COPD alone. Results suggest a potential role for metformin in ACO which requires further prospective study.