Sarcoidosis Vasc Dif
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Sarcoidosis Vasc Dif · Dec 2008
Comparative StudyBronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis.
End-stage sarcoidosis is characterized by severe pulmonary fibrosis and is often poorly responsive to medical therapy. Lung transplantation, therefore, may be the only treatment option. Currently, there are few studies evaluating long-term outcomes following transplantation for these patients. Our aim was to evaluate post-transplant morbidity and survival of patients with sarcoid compared to recipients transplanted for idiopathic pulmonary fibrosis (IPF). ⋯ We observe similar long term outcomes following lung transplantation for sarcoid and IPF recipients. Transplantation remains a treatment option for end-stage sarcoidosis, as BOS and survival rates are comparable to IPF.
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Sarcoidosis Vasc Dif · Dec 2008
Comparative StudyEffects of oxygen on exercise-induced increase of pulmonary arterial pressure in idiopathic pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a severe disease with no known effective therapy. Patients with IPF may develop severe increase of pulmonary arterial pressure (PAP) on exercise, the mechanisms of which is not clearly identified. ⋯ Our results demonstrate that oxygen does not improve exercise-induced increase of PAP in patients with IPF and support the hypothesis that hypoxic vaso-constriction is not the main mechanism of acute increase of PAP during exercise.