Chinese J Physiol
-
The present study was conducted to assess the effects of whole body cooling on multiorgan dysfunction that occurred during heatstroke in streptozotocin (STZ)-induced diabetic rats. The rats were randomly divided into four groups: [1] the normal control, [2] diabetic control, [3] diabetic heatstroke, and [4] diabetic heatstroke-whole body cooling (WBC). They were exposed to ambient temperature of 43 degrees C for exactly 58 min to induce heatstroke. ⋯ The cerebrovascular, renal, and hepatic dysfunction, the increased levels of nitric oxide metabolites, tumor necrosis factor-alpha, and dihydroxybenzoic acid in the serum during heatstroke were significantly reduced by WBC. Although the serum interleukin-10 maintained at a negligible levels before heat stress, they were significantly elevated by WBC in diabetic-heatstroke rats. The data demonstrate that heatstroke-induced multiorgan dysfunction in streptozotocin-induced diabetic rats can be decreased by WBC.