The Medical journal of Australia
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To describe the clinical picture of the syndrome of terminal restlessness in dying patients and the role and mode of administration of midazolam. ⋯ Midazolam given by the subcutaneous route can usually provide effective palliation of terminal restlessness when other measures are ineffective. The drug is also useful for providing short-term sedation for uncomfortable procedures and for managing catastrophic terminal events.
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Case Reports
Pancytopenia after accidental overdose of methotrexate. A complication of low-dose therapy for rheumatoid arthritis.
Pancytopenia is an unusual complication of low-dose methotrexate therapy in rheumatoid arthritis. We report a near fatal case that followed an accidental overdose. ⋯ Low-dose methotrexate therapy is uncommonly associated with haematological toxicity. This generally occurs in patients with known risk factors for such reactions. Patient reliability should be considered if methotrexate therapy is contemplated.