Restor Neurol Neuros
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Restor Neurol Neuros · Jan 2001
Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury.
Cyclosporin A (CsA) is widely used in clinical situations to attenuate graft rejection following organ and central nervous system transplantation. Previous studies demonstrated that CsA administration is neuroprotective in models of traumatic brain injury (TBI). However, no studies, to date, have evaluated the influence of post-injury CsA administration on behavioral recovery after TBI. ⋯ These data suggest that daily post-injury treatment with CsA improves certain aspects of motor and sensorimotor function following experimental TBI.
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Restor Neurol Neuros · Jan 2001
Selective fascicular stimulation of the rat sciatic nerve with multipolar polyimide cuff electrodes.
To assess a new flexible, multicontact spiral-cuff electrode made of polyimide with integrated platinum contacts for selective stimulation of nerve fascicles. ⋯ Despite the relative small size of the rat sciatic nerve and the close apposition of tibial and peroneal fascicles, we proved the feasibility of using multipolar polyimide cuff electrodes to produce selective fascicular nerve stimulation.