Arch Dermatol
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A randomized, placebo-controlled comparison of oral valacyclovir and acyclovir in immunocompetent patients with recurrent genital herpes infections. The Valaciclovir International Study Group.
To compare valacyclovir hydrochloride with acyclovir in the treatment of recurrent genital herpes infection. ⋯ Twice-daily valacyclovir was as effective and well tolerated in the treatment of recurrent genital herpes simplex virus infection as 5-times-daily acyclovir. Therefore, valacyclovir could prove a useful alternative to acyclovir when convenience of dosing or compliance issues are the prime considerations in treatment.