Arch Dermatol
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Randomized Controlled Trial Comparative Study Clinical Trial
Topical cyproterone acetate treatment in women with acne: a placebo-controlled trial.
To evaluate the clinical and hormonal response of topically applied cyproterone acetate, oral cyproterone acetate, and placebo lotion in women with acne. ⋯ The therapeutic effect of topically applied cyproterone acetate for acne treatment was clearly demonstrated. Topically applied sexual steroids in combination with liposomes are as effective as oral antiandrogen medication in acne treatment, while reducing the risk of adverse effects and avoiding high serum cyproterone acetate concentrations.