Minerva medica
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Randomized Controlled Trial
Is hyaluronate sodium effective in the management of knee osteoarthritis? A placebo-controlled double-blind study.
The aim of this study was to investigate the effect of intra-articular hyaluronic acid (HA) injection on pain and function in knee osteoarthritis (OA). ⋯ HA treatment was effective in the management of knee OA and improved knee pain and functional outcome, but there was no statistically significant difference in functional and symptom improvement with respect to saline (placebo) injection.