Minerva medica
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Novel treatments target eosinophilic inflammation in type 2 asthma. We aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate. ⋯ Monoclonal antibodies have proven their benefit to reduce exacerbation rates in severe persistent eosinophilic asthma in the published trials. No biological showed superiority over the others emphasizing the need for clearly defined endotypes indicating those patients who will optimally benefit for each treatment.
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Comparative Study
Efficacy evaluation of different conservative treatments for blunt spleen rupture.
This study aimed to provide a reference for the clinical treatment of patients with spleen ruptures by analyzing and discussing the clinical effects of the conservative treatment. ⋯ Conservative treatment is feasible in blunt spleen rupture patients of CT classification grade of 1-4 with stable hemodynamical. Splenic rupture patients of CT classification grade 4-5 with instable hemodynamical should be treated surgically.