J Am Assoc Lab Anim
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J Am Assoc Lab Anim · Sep 2007
Study of two devices used to maintain normothermia in rats and mice during general anesthesia.
Rodents are very susceptible to hypothermia during anesthetic events because of their high body surface-to-mass ratio. This study examined the effectiveness of 2 heating devices, a heatpad and a circulating hot-water blanket, during 60 min of isoflurane general anesthesia in rats and mice (n = 6 per treatment). In addition, 1 control group of animals for each species was anesthetized with no heat source (n = 6). ⋯ Although statistically significant, these deviations from baseline body temperature were not considered physiologically relevant. In comparison, body temperatures decreased significantly in rats and mice (4.42 +/- 0.60 and 9.90 +/- 0.35 degrees C, respectively) with no heat source. Both heating devices were safe and effective, but the low cost, ease of maintenance, and portability of the heatpad may make it a more desirable choice in some facilities.
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J Am Assoc Lab Anim · Sep 2007
Baseline hemodynamics in anesthetized landrace-large white swine: reference values for research in cardiac arrest and cardiopulmonary resuscitation models.
The use of swine in cardiopulmonary resuscitation (CPR) research has increased in the last decades. Landrace-Large White (LLW) swine are a farm breed of pigs. ⋯ The mean pressures of the right atrium were 10.93 +/- 1.36 mm Hg (systolic) and 4.10 +/- 1.01 mm Hg (diastolic), whereas the value obtained by using near-infrared spectroscopy to determine brain regional oxygen saturation was 64.55% +/- 3.88%. LLW can be considered a suitable breed for CPR research because of the close similarity of its hemodynamic values to those of humans.