J Am Assoc Lab Anim
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J Am Assoc Lab Anim · May 2008
The effects of depth of isoflurane anesthesia on the performance of mice in a simple spatial learning task.
Studies on humans and rodents indicate possible long-term cognitive impairment after surgery or general anesthesia. The goal of this study was to evaluate the effect of various anesthetic concentrations on spatial learning in adult mice. ⋯ The performance of the mice anesthetized with 2% isoflurane was not statistically different from that of the control group. Therefore, low, not high, isoflurane concentration impaired spatial learning in mice.