Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Oct 1992
Randomized Controlled Trial Multicenter Study Clinical Trial[Prevention and treatment of respiratory distress syndrome in premature infants using intratracheally administered surfactants].
To study the effects of administration of surfactant immediately after birth (prophylactic) or after 6 hr (therapeutic) to 81 Dutch preterm infants from a multicentre trial. ⋯ Surfactant, given either prophylactically or therapeutically, results in clinical improvement of children with biochemically immature lungs. A prophylactic treatment, moreover, results in reduced incidence and severity of RDS, in a significant shortening of the time spent on the respirator and in reduced need of extra oxygen compared with therapeutic treatment. We recommend to give surfactant prophylactically or at the first signs of RDS.