Nederlands tijdschrift voor geneeskunde
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Ned Tijdschr Geneeskd · Aug 2001
Case Reports[Abdominal pain and vomiting: a 4-year old boy with relaxation of diaphragm].
A 4-year-old boy presented with vomiting, abdominal pain and a visible swelling on the left side of the upper abdomen. He had been generally unwell for a week, and had been suffering from constipation for a longer period of time. Radiological examination revealed a large space containing air and fluid in the left side of the upper abdomen and the chest region. ⋯ Patient recovered well and remained without complaints. Diaphragm relaxation is rare, and can be either congenital or acquired. Unlike congenital diaphragmatic hernia, diaphragm relaxation is characterised by an elevated diaphragm which, although intact, is hypoplastic.
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Ned Tijdschr Geneeskd · Aug 2001
Review[Uneasiness about the safety of bupropion as an aid to smoking cessation unjustified ].
A report in a national newspaper on Thursday 26 April 2001, linked the anti-smoking drug bupropion to 41 deaths. From the reports of suspected adverse reactions received by the Netherlands Pharmacovigilance Foundation, it appears that more than half the cases concerned patients at risk of developing smoking-related diseases. In 15 cases, the simultaneous use of bupropion and another antidepressant (10 patients), theophylline (1 patient) or insulin (4 patients) was reported, even though these combinations may lead to an increase in the risk of seizures. ⋯ Provided that bupropion is used according to the guidelines in the product information, this new aid in smoking cessation is considered an effective and safe drug. It is highly unlikely that bupropion has contributed to any deaths. If prescribed appropriately and in combination with counselling (e.g. minimal intervention strategy), bupropion is as yet the most effective aid in helping people stop smoking.