Acta Medica Port
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Next-generation sequencing (NGS) has been implemented in clinical oncology for diagnosis, prognosis, and therapeutic guidance. Among the various NGS applications in molecular oncology, we focused on the following topics: laboratory standards for targeted gene panels (somatic mutations) and therapeutic guidance based on NGS of lung cancer and rare cancers, namely sarcomas and cancers of unknown primary. Multiple quality control checkpoints should be addressed in the pre-analytical phase for good quality and interpretation of the NGS results. ⋯ Moreover, other patients with other incurable solid tumors may benefit from being included in biomarker-driven clinical trials. Multidisciplinary tumor boards with the participation of experts with the ability to integrate genomic profiling data are essential to tailor the best strategy for each patient. Considering that there are no national guidelines, this article aims to guide laboratory and clinical practice for the use of NGS in the context of lung cancer, rare tumors, and cancer of unknown primary in Portugal.
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Hyperpigmentation of the tongue has been associated with chemotherapy, specifically cytotoxic drugs, but the exact pathophysiological mechanism is still not well understood. We describe a 37-year-old black woman that presented with tongue hyperpigmentation one week after the initiation of chemotherapy with temozolomide as a single agent. ⋯ The tongue hyperpigmentation is usually self-limited. This case constitutes a challenge for healthcare professionals and patients and emphasizes the importance of documenting these cases in order to guide healthcare professionals in managing the expectations of the patients and the potential adverse effects associated with certain drugs.
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The implementation of policies aimed at promoting smoking cessation led to a decrease in the use of tobacco. There has been an increase in the use of systems such as electronic nicotine delivery systems and electronic non-nicotine delivery systems - also known as electronic cigarettes, and heat-not-burn tobacco products. The aim of this review is to describe the pathophysiological implications of these devices and their perioperative impact. ⋯ Awareness of the potential harmful effects of these devices, and their perioperative implications, is essential, as it enables the implementation of interventions to minimize the risks and improve patient outcomes.
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Addictive use of the Internet among adolescents has been linked to a negative psychosocial development, but more detailed information about Internet addiction (IA) profiles is warranted. The aim of this study was to identify IA profiles in adolescents based on psychometric properties from the Internet Addiction test (IAT), and to assess the associations between the profiles and personal/social behaviors. ⋯ This study provides a characterization of different patterns in adolescents' traits and behaviors associated with Internet addiction. Preventive approaches may be useful to reduce IA.
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On page 646, Section 'RESULTS',On paragraph 'Model estimation and selection',Line 3, where it reads (in red):Firstly, we examined fit statistics (Table 5), namely the Akaike Information criterion (AIC) (...)It should read (in blue):Firstly, we examined fit statistics (Table 3), namely the Akaike Information criterion (AIC) (...)Line 9, where it reads (in red):(...) (LRT = 57.33, p < 0.0001, see Table 5) (...)It should read (in blue):(...) (LRT = 57.33, p < 0.0001, see Table 3) (...)On paragraph 'Classification accuracy of the model',Line 1, where it reads (in red):The probabilities of correct classification of observations are shown in the main diagonal of Table 6, (...)It should read (in blue):The probabilities of correct classification of observations are shown in the main diagonal of Table 4, (...)Line 7, where it reads (in red):The classification accuracy of the testing subsample was 96%, as shown in Table 7. It should read (in blue):The classification accuracy of the testing subsample was 96%, as shown in Table 5. On page 647,Chapter Description of profiles, 2nd paragraph, line 4, where it reads (in red):This group scores negatively (less than 2.5, below the green, dotted bottom line) in all dimensions (Table 3), (...)It should read (in blue):This group scores negatively (less than 2.5, below the green, dotted bottom line) in all dimensions (Table 6), (...)On page 648,Line 6, where it reads (in red):(...) equal parental control rates or absence thereof (Table 4). ⋯ It should read (in blue):Here we also highlight users with the least difficulty in making friends (Table 7).4th paragraph, line 10, where it reads (in red):(...) and lower parental control rate stood out compared with the other profiles (Table 4). It should read (in blue):(...) and lower parental control rate stood out compared with the other profiles (Table 7). Article published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17047.