Ann Acad Med Singap
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Erythema induratum remains one of the rarely encountered tuberculid although tuberculosis is known to be endemic in the developing countries. We report a case of erythema induratum recently encountered in our centre. ⋯ A short review of the distinguishing features of erythema induratum, the associated classical histological spectrum and the usefulness of polymerase chain reaction in the diagnosis of erythema induratum is given. A search for active foci of tuberculosis is advocated in all cases.
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This paper presents the regulatory perspectives of the clinical drug evaluation process and the role of the newly established Centre for Drug Evaluation in Singapore in this process. It describes the major drug evaluation systems in the developed countries and their similarities and differences. ⋯ Building the capability for the evaluation of new drugs is essential as part of the regulatory infrastructure for a knowledge-based economy in Singapore. To conduct better clinical trials, investigators should develop a good understanding of the clinical drug evaluation process and an appreciation of the regulatory angle.