Ann Acad Med Singap
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Ann Acad Med Singap · Jun 2014
Case ReportsNeonatal Diabetes in a Singapore Children's Hospital: Molecular Diagnoses of Four Cases.
Neonatal diabetes (ND) presents below 6 months of age, and is caused by a genetic defect in glucose homeostasis. Molecular genetic diagnosis can identify the exact molecular aetiology and guide clinical management. The objective of this study was to identify ND among children with diabetes in a major children's hospital in Singapore and to characterise their molecular and clinical features. ⋯ This study identified 4 cases of ND in our cohort of diabetes children and confirmed their molecular diagnosis. Molecular genetic testing for these children led to accurate diagnosis and appropriate management.