Arch Iran Med
-
Observational Study
Multiple Sclerosis in Tehran: Rising Prevalence alongside Stabilizing Incidence - True Increase or Enhanced Diagnosis?
Multiple sclerosis (MS) is a chronic and potentially progressive demyelinating disease of the central nervous system. The incidence and prevalence rate of the disease has been increasing globally, especially in females. ⋯ Tehran is among MS high-risk areas with increasing trends in prevalence and increasing followed by plateaued incidence rates indicating necessity of extra investigations of the underlying reasons and health system preparedness for further health care requirements of MS patients.
-
Mutations and polymorphisms of the GSK3β gene have been associated with several diseases including Alzheimer disease, diabetes and cancer; however, to date, no variants of this gene have been associated with colorectal cancer (CRC). This study aims to explore, for the first time, the association of the GSK3β rs334558 and rs6438552 polymorphisms with CRC. ⋯ Our results denote that GSK3β gene polymorphisms play a significant role in promoting or preventing CRC. Additionally, variations in this gene are associated with the tumor site and the tumor-node-metastasis (TNM) stage in these patients.
-
Letter Historical Article
Burnt City and the Evolution of Cognitive Science.