Arch Iran Med
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Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Liver transplantation, surgical liver resection, chemotherapy, and radiotherapy are the main options for the treatment of HCC. However, these methods are unable to limit the growth, survival, and metastasis of HCC cells. ⋯ The anti-cancer effects of molecular agents can be evaluated directly in animal models or indirectly through the injection of HCC cell lines treated with anti-cancer agents. Targeting cancer-specific signaling pathways with miRNAs can be novel therapeutic strategies against HCC. This study provides the latest findings on using miRNAs in the control of HCC in both in vitro and in vivo models.
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Randomized Controlled Trial
Effect of Prophylactic Caffeine on Noninvasive Respiratory Support in Preterm Neonates Weighing 1250-2000 g: A Randomized Controlled Trial.
Caffeine is commonly used to prevent or treat apnea in preterm neonates. The present trial was designed to determine the effect of caffeine on reducing the time required for nasal continuous positive airway pressure (NCPAP) in neonates with respiratory distress syndrome (RDS). ⋯ The results suggest that preventative caffeine can reduce the duration of NCPAP support in neonates with RDS.
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In the last two decades, the simple low-cost abdominal ultrasound (US) examination for the diagnosis of advanced fibrosis and cirrhosis was displaced by very expensive and not readily available modern imaging systems like magnetic resonance imaging (MRI), computed tomography (CT) scan and transient elastography. The aim of this study is to evaluate and emphasize the potential of US for diagnosis of advanced liver fibrosis and cirrhosis. ⋯ The simple US examination, alone or combined with lab data, is able to diagnose advanced fibrosis and cirrhosis with excellent accuracy, making the use of other modern imaging modalities unnecessary.
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The financing function within a health system is considered inherently complex, so it is of utmost importance to design a suitable future for this system given uncertainties and complexities of the environment. With regard to the current and future complicated conditions, health system financing is also likely to succeed if it can anticipate the impacts of effective factors in the future and further plan appropriate interventions ahead of time. Thus, the purpose of this study was to develop scenarios for the health system financing in Iran. ⋯ The best scenario identified in this study based on the degree of adaptation included the use of massive technology and oil sales, mediocre economic conditions with high probability of occurrence, strong leadership and advocacy, high regional security, as well as bureaucracy and low corruption with medium probability of occurrence.