Arch Med Sci
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Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension. ⋯ ET-1 and ETA gene polymorphisms are prevalent in the PH-MVD group suggesting that they may predispose to the development of PH.
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Identifying SARS-CoV-2 patients at higher risk of mortality is crucial in the management of a pandemic. Artificial intelligence techniques allow one to analyze large amounts of data to find hidden patterns. We aimed to develop and validate a mortality score at admission for COVID-19 based on high-level machine learning. ⋯ Machine learning techniques were applied in order to develop an accurate in-hospital mortality risk score for COVID-19 based on ten variables. The application of the proposed score has utility in clinical settings to guide the management and prognostication of COVID-19 patients.
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The nanoparticle has become a part of world industry. This substance has been proven as potentially beneficial for its usage as a catalyst and semi-conductor due to its high surface area and the effects of the quantum size effect. It exhibits potential characteristics and would be applied in a wider scope of usage compared to bulk particles because the smaller the size of the particles, the more room for the extent of their usage. Nano titanium dioxide application as semi-conductors together with a catalyst is highly attributed to its high photochemical stability and ability to be produced at a low-cost. The consequence of this - exposure of nano titanium dioxide particles to humans - raises concerns regarding health and safety. Therefore, this research action works designed to offer a thorough analysis of toxicology impacts produced by our own synthesis modified hydrothermal in vitro experiments. ⋯ There is no cytotoxic effect of nanotitania extraction with 0.05% silver in the growth inhibition test with L929 mouse with the exception of the 100 mg/ml extract.
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The function of the C6orf120 gene, which encodes an N-glycosylated protein, remains unknown. The study was performed to characterize the utility of the C6orf120 gene in carbon tetrachloride-induced acute liver injury and to elucidate the potential underlying mechanisms by establishing a C6orf120 gene-knockout (C6orf120-/-) rat model. ⋯ C6orf120-/- rats were susceptible to CCl4-induced liver injury, which may be related to NLRP3 inflammasome and JNK signaling pathway activation.
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The increased risk of myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) is well documented. Polymorphisms in APOA1 and APOB genes allow us to identify new genetic markers in the Mexican population with T2DM and MI. ⋯ The -75 G>A APOA1 polymorphism could be considered as a susceptibility factor for myocardial infarction in individuals with T2DM and 2488 C>T APOB polymorphism is associated with changes in HDL-C and LDL-C and triglycerides in the same group.