Arch Med Sci
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This study aimed to explore the effect of curcumin on the activity of lipopolysaccharide (LPS)-induced proximal renal tubular epithelial cells (PRTECs) and to analyze the molecular mechanism by which curcumin regulates their occurrence. ⋯ Curcumin inhibits LPS-induced PRTEC death by regulating ADAMTS18 methylation and AKT/Notch pathways.
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The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity. ⋯ This research demonstrated the potential value of CD39 on CD8-positive T lymphocytes as a negative regulator in cancer immunotherapy.
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Previous studies have reported that microRNAs are implicated in the pathogenesis of diabetic nephropathy (DN). In this study, the underlying molecular mechanisms and diagnostic significance of miR-372-3p were investigated in the process of DN. ⋯ miR-372-3p might be a valuable therapeutic target and diagnostic marker for patients with DN.
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The aim of this study was to evaluate the effects and mechanisms of salvianolic acid B (Sal B) in preeclampsia treatment by in vivo and in vitro study. ⋯ Sal B improved preeclampsia via regulation of miRNA-155/CXCR4 in the in vitro and vivo study.
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This study examines the feasibility of SilverCloud therapy for anxiety and/or depression. Findings may help determine SilverCloud effectiveness based on patients' profiles. ⋯ This SilverCloud study shows feasibility for participants who had moderate to severe anxiety and/or depression due to social, behavioral, or economic reasons.