Arch Med Sci
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We aimed to evaluate the serum level of miRNA-27 expression in patients with familial hypercholesterolemia (FH). ⋯ We observed higher miRNA-27a/b expression in patients with FH than in healthy individuals. In comparison with HoFH and HeFH groups, the former had a higher expression level of miRNA-27a/b, which indicates the potential of miRNA-27a/b as a candidate marker for the severity of disease in individuals with FH.
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In the occurrence and development of heat stroke (HS), factors such as hyperthermia, ischemia and hypoxia are essential to the central nervous system (CNS) inflammatory response, but the main mechanism underlying CNS inflammation remains unclear. The aim of the study was to observe the polarization of microglia in response to heat-induced early nerve injury and to explore its possible mechanism of action. ⋯ After heat-induced disease, microglia were found to be active in the brain tissues of dogs. The microglia activated in the early 1-6 h of CNS injury were mainly the M1 type, which were then converted to the M2 type after 6 h. The 24 h M2 type was dominant. The relationship between M1/M2 polarization trends and early brain injury in heat-induced disease may be a key to understanding CNS injury in heat-induced disease.
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A decreased insulin-like growth factor 1 (IGF-1) level has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro research has shown that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1. The study aim was to compare the IGF-1 and IGF-2 concentrations depending on HF exacerbation and annual survival. ⋯ Reduced IGF-2 concentration is a better marker of patients with more advanced HF and a higher 1-year death risk than low IGF-1. Its secretion may depend on the cholesterol concentration.
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Rheumatoid arthritis (RA) is a chronic inflammation resulting in the involvement of all the structures constituting a joint. We determined the type and severity of foot deformities, determined the impact of the degree of disturbances of foot statics and the disease activity on the duration of the particular phases of gait, determined the impact of the maximum foot load and the percentage distribution of loads between the forefoot and hindfoot on the duration of the particular phases of gait, and established the link between observed disorders and the stage of rheumatoid arthritis. ⋯ Our results confirm the usefulness of baropodometric examination as an important diagnostic tool in the evaluation of the locomotor system of RA patients.
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The study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer. ⋯ Telomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.