B Acad Nat Med Paris
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B Acad Nat Med Paris · Mar 2007
[Whole-body ultrasound in the ICU. A visual approach to the critically ill].
Sonography is a non invasive method allowing prompt diagnosis at the bedside, especially when sophisticated diagnostic tools are unavailable, as in the critical care setting. In particular, the lung, a vital organ, is fully accessible, and the signs are simple and standardized. ⋯ The clinical relevance of these diagnoses, and especially the interstitial syndrome, is discussed. Sonography also allows cost savings and avoids unnecessary irradiation.
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B Acad Nat Med Paris · Mar 2007
Review Comparative Study[Essential thrombocythemia. Contribution of the V617F JAK2 mutation to the pathophysiology, diagnosis and outcome].
An increased platelet number in blood depends on a limited spectrum of causes, which aren't always simple to identify. Secondary thrombocytosis is a reactive process in relation with acute or chronic inflammatory diseases, or asplenia. The infrequent inherited thrombocytoses disorders are suspected when similar cases are observed in the same family. ⋯ Disease stratification and treatment strategy are targeted on the evaluation and prevention of vascular complications. Acute leukaemia or myelodysplasia, and other clonal progressions like myelofibrotic transformation, are infrequent and delayed events. However, according to the present data, the risk of fibrotic progression or of leukaemic transformation is not related to the mutation status of ET patients.
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B Acad Nat Med Paris · Mar 2007
Review Comparative Study[Intraepithelial lesions and neoplasia associated with human papillomavirus infection].
Anogenital lesions induced by human papillomaviruses (HPV) are due to both high-risk HPV types involved in carcinogenesis of the cervix (and also, to a lesser extent, of the vulva, anus and vagina) and to low-risk HPV types that cause external genital warts in the perianal region, perineum, vulva and vagina (less often the cervix). Cervical cancer is thus virus-induced, and there is a continuum from intraepithelial lesions to invasive cancer. This offers the opportunity to screen cervical smears for cytological abnormalities or to detect high-risk HPV infection by molecular methods. Although the causal link between human genital papillomavirus infection and cervical neoplasia is well established, the role of beta-HPV in non melanoma skin cancers is unclear.