B Acad Nat Med Paris
-
B Acad Nat Med Paris · Jan 2013
Review[Heart rate variability: a cardiometabolic risk marker with public health implications].
Heart rate variability (HRV) is a noninvasive, practical and reproducible measure of autonomic nervous system function. Although the heart is reasonably stable, the time between two beats (R-R) can be very different. HRV is the time variation between two consecutive heartbeats. ⋯ HRV may also have predictive value for life expectancy and health. HRV changes due to lifestyle factors precede the onset of cardiovascular disorders. Measurement of HRV and its components is of major interest for medical practitioners and public health specialists, in order to predict and evaluate the risk of cardiometabolic events related to lifestyle factors.
-
Rare cancers are defined by an annual incidence below 6/100 000 new cases. According to this definition, 20% of malignancies in the European Union are rare cancers. These cancers are associated with considerable excess mortality, as they account for close to 30% of all cancer deaths within the E. ⋯ With the increasing fragmentation of frequent tumors into subsets of rare tumors, as exemplified by lung cancer, many frequent tumors will need to be managed with approaches similar to those developed in recent years for rare cancers. In the age of routine molecular biology, the challenges of clinical research on rare tumors are thus becoming the challenges of all clinical research in oncology. This will required extensive multinational collaboration within the European Union and beyond.