Bratisl Med J
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Pulmonary oxygen toxicity is very well known and proved. The influence of hyperoxia on the respiratory reflexes is not known till now. ⋯ Long-lasting breathing of PNO induced changes of respiratory reactions elicited mainly from upper airway.(Fig. 6, Tab. 3, Ref. 22)
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The cardio-respiratory interactions include mechanical, reflex and humoral mechanisms. However, in the organism they mutually overlap, thus mating their separate investigation is problematic. Mechanical effects of conventional artificial ventilation (AV) and high frequency ventilation (HFV) are elicited by increased intrapulmonary pressure during lung inflation, as well as during application of positive end expiratory pressure (PEEP). ⋯ The reflex effects of artificial ventilation are due to the activation of baroreflexes and pulmo-vagally cardiac and vasoactive reflexes. Activation of these reflexes depends on the level and characteristic of the pressure in the airways, lungs, heart and vessels. Humoral effects of AV on the cardiovascular system and hemodynamics are triggered by lung expansion, circulatory changes, and they result in a release of vasoactive substances from lung parenchyma. (Fig. 5, Ref. 45.)
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Gastroesophageal reflux (GER) is a common cause of chronic cough. It has been suggested that GER most often causes chronic cough by stimulating the distal oesophagus. Possible mechanisms of this interactive process are: a) an oesophageal-tracheobronchial reflex, b) acid reflux seems to be only a cofactor of cough; it decreases cough threshold. ⋯ The oesophageal-tracheobronchial reflex mechanism for either induction or modulation of cough is not present in healthy anaesthetised cats. We agree with previous data that GER alone is not trigger agent of cough. (Fig. 5, Ref. 17.)