Bratisl Med J
-
The effect of hyponatremia on the body is studied on model objects. The related question concerns the degree of compliance between manifestations of hyponatremia and protective mechanisms in humans and other species of vertebrates. ⋯ The data regarding mammals are fragmented and reflect the manifestation of protective mechanisms taking place during the initial period of hyponatremia. The method tested on freshwater fish allows for studying patterned changes in inorganic ions and content of organic osmolytes in the internal environment and cells of various organs and tissues of the body from the start of developing hyponatremia till the completion of the recovery process in vivo (Fig. 2, Ref. 72).
-
The purpose of this research was to examine the suppressing effect of caffeic acid (CA) on colon cancer cells triggered by an overdose of H2O2, and molecular mechanisms involved. ⋯ In light of all these findings, the antioxidant use should be paid attention to as it could decrease the level of ROS, and in turn decrease the apoptotic cell death which is an unwanted situation in the setting of cancer remedy. Overall, these data revealed that CA can suppress apoptosis in HT-29 cells triggered by an overdose of H2O2 (Fig. 5, Ref. 37).
-
Breast cancer is the most common type of cancer in women worldwide. Our aim is to evaluate the importance of immunotherapy in breast cancer cases by using PD-L1 expression and to determine the effect of Maspin expression and lymphocytic density on predicting the prognosis. ⋯ In our study, PD-L1 expression was detected in breast cancer, and was associated with triple negativity and high grade. Our results show that the Maspin expression and lymphocyte density are associated with the prognosis (Tab. 5, Fig. 4, Ref. 44).
-
The failure of pancreatic anastomosis after the proximal pancreaticoduodenectomy (PD) and the failure of pancreatic stump after the distal pancreatectomy with a resulting postoperative pancreatic fistula remain the most feared complications after pancreatic resection. Surgeons have been trying to find a reliable reconstructive technique of pancreatic anastomosis for decades. ⋯ Grade C POPF following PD, although uncommon, occurs with a defined incidence and is associated with a substantial morbidity, prolonged hospitalization, delayed recovery and a significant mortality. According to the results of various meta-analyses, pancreatogastrostomy and pancreatojejunostomy seemed to be comparable anastomotic techniques following PD (Ref. 54).
-
The aim of this study is to examine the health anxiety states and behaviours of athletes during the social isolation period due to COVID-19 pandemic. ⋯ The results of this study showed that the COVID-19 pandemic and social isolation process have some effects on athletes' health anxiety. It will be beneficial to provide psychological support in this period for athletes to have a fast return to competitions and match after the pandemic (Tab. 5, Ref. 24).