Bratisl Med J
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In this study, we analysed the results of magnetic resonance spectroscopy (MRS) in the patients with gliomas, including the error rate, MRS parameters variability, correlations with gene mutations and overall usefulness for clinical practice. ⋯ MRS brings an added value to multiparametric MRI evaluation of brain tumours in the patient follow-up after an initial surgery, especially in ambiguous findings (Tab. 5, Fig. 2, Ref. 29).
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The global impact of COVID-19 pandemic has gained momentum rapidly. People have little information about SARS-CoV-2 (Coronavirus). Internet has become a frequently used tool to obtain information in recent years, while YouTube is one of the popular sources of information with many videos on its platform. This study aims to identify the topics regarding Coronavirus that people learned about on YouTube. The videos about Coronavirus were also evaluated in terms of the reliability of their source of information. ⋯ It has been determined that the videos about the symptoms, diagnosis and treatment of COVID-19, and those with scientific content have the most reliable source of information on Coronavirus (Tab. 5, Fig. 1, Ref. 35). Text in PDF www.elis.sk Keywords: coronavirus, SARS-CoV-2, COVID-19 pandemic, coronavirus pandemic, latent Dirichlet allocation, information, YouTube.
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To investigate the association between maternal serum neutrophil-to-lymphocyte ratios (NLRs) and pregnancy outcomes in women with familial mediterranean fever (FMF). ⋯ The NLRs are a haematological parameter that can be used to predict subclinical inflammation and the effects of ongoing subclinical inflammation on the pregnancy outcomes in women with FMF (Tab. 4, Ref. 39).
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miR-145 suppresses epithelial-mesenchymal transition by targeting stem cells in Ewing sarcoma cells.
We aimed to examine the performance of stem cell markers and epithelial-mesenchymal transition (EMT) process in miR-145 transfected EWS cells (TC71, TC106). ⋯ This is the first time in the literature we have shown deregulation of miR-145 inhibits EMT process by targeting stem cell properties leading to the inhibition of tumor growth and metastasis in TC71 and TC106 cells. Based on these results, we propose that miR-145, as an important regulator of SOX2, KLF4 and OCT4 carries crucial roles in EWS tumorigenesis and EMT (Tab. 1, Fig. 4, Ref. 26).
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Anti-inflammatory effect of vitamin D (VD) could be beneficial in improving the survival of glioma patients. The aim of our study was to analyse the serum levels of vitamin D in glioma patients and to find an association with the prognosis of glioma patients and other investigated parameters. ⋯ Levels of VD could influence the prognosis of patients with high-grade gliomas. Serum level of 25(OH)D in low-grade gliomas positively correlated with the percentage of anti-inflammatory acting TREM-2+ monocytes and negatively with TREM-1/TREM-2 ratio. This could be protective against the progression to high-grade glioma, because TREM-2 is associated with protective functions such as: tissue repair, control of local inflammation, or phagocytosis (Tab. 4, Fig. 4, Ref. 79).