Bratisl Med J
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Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) are markers reflecting the inflammation process that can be easily calculated in the hemogram examination. In this study, we aimed to investigate the changes in NLR, PLR and MPV values in patients who attempted suicide by taking drugs. ⋯ The high detection of these markers of inflammation suggests that it may be a marker predictive of suicide attempt by taking medication (Tab. 4, Ref. 28).
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Abnormal neutrophil extracellular traps are associated with lung diseases, thrombosis, increased mucosal secretion in the airways. The aim of this study is to evaluate the possible place of the most specific NETosis marker Cit-H3 protein in diagnostic algorithms by revealing its relationship with the severity, mortality and prognosis of SARS-CoV-2 pneumonia. ⋯ Cit-H3 plays a role in inflammatory processes in SARS-CoV-2 pneumonia, and changes in serum Cit-H3 levels of these patients can be used to determine prognosis and mortality (Tab. 5, Fig. 1, Ref. 21).
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Life expectancy of cancer patients determine the regimen of treatment. There is no feasible marker that determines the survival other than the stage of the disease or other patients related factors. Bilirubin can be a revealing marker for these. The effect of bilirubin may be due to the fact that the genetic and biochemical processes of bilirubin also modulate the tumour microenvironment. Radiotherapy and bilirubin can produce an effect similar to metformin via AMPK pathway. ⋯ Plasma bilirubin level at the time of diagnosis affects the survival of the patients independent of cancer stage and tumour volume. Possible additive interactions of radiotherapy and bilirubin are discussed with their pathophysiological mechanisms (Tab. 2, Fig. 7, Ref. 26).
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The present study evaluated vitamin D therapy in migraine patients with vitamin D deficiency and EEG abnormality. ⋯ Vitamin D therapy positively affects attack frequency and PedMIDAS scores in migraine patients with vitamin D deficiency/insufficiency. No association was determined between EEG findings and vitamin D levels or therapy (Tab. 6, Ref. 35).
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The aim of this study is to investigate the effects of factors such as age, gender, comorbid diseases and treatments applied on the positive duration of the PCR test in COVID-19 patients. ⋯ In COVID-19 infection, there are several factors that affect the PCR test to remain positive. Early-term favipiravir use may shorten this period as a modifiable factor (Tab. 3, Ref. 14).