Bratisl Med J
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The repeated exposure of normal cells to carcinogenic agents may lead to mutations in their genetic material, changing them into cancerous cells. In this case, the structure and function of these cells would alter, and they would not behave like a normal cell. Treatment of cancer by bacteria is a promising and new strategy. ⋯ Besides describing H. pylori virulent factors and their role in cancer incidence, we also discuss how their potentials can significantly be strengthened and used for cancer treatment. This review results suggest that some factors of H. pylori can be exploited as therapeutic agents for cancer therapy in future (Tab. 1, Fig. 3, Ref. 77). Keywords: apoptosis induction, bacteriotherapy, cancer treatment, Helicobacter pylori.
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Review
Novel and emerging concepts in the role of steroids in thyroid cancer promotion and progression.
Thyroid cancer (TC) is becoming more common all over the world. It is, however, frequently neglected from a scientific standpoint, as they rarely result in a fatal conclusion. The female gender is disproportionately affected, with a frequency of 3 to 5 times higher depending on the severity of the condition, which may or may not cause severe physical discomfort but has a significant influence on life quality. ⋯ On the contrary, excessive or uncontrolled exposure to different hormones, particularly steroids, has been shown to impact the development of thyroid illnesses. The goal of this review is to look at the function of steroids in the expansion and progression of thyroid malignancy (Ref. 54). Keywords: thyroid cancer, signaling, steroid hormone.
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This survey was aimed to obtain the characteristics of physicians operating in mass vaccination sites (MVS), emphasizing their motivation to work there. ⋯ The financial aspect was the most important motivational factor among residents, while moral responsibility was decisive for the attending physicians. Physicians, who participated in MVS as a work duty presented both the most prevalent self-perceived burnout syndrome (32 %) and the hesitancy (48 %) to work in MVS again in the future (Tab. 4, Ref. 15) Keywords: mass vaccination site, COVID-19; healthcare workers, vaccination, SARS-CoV-2, coronavirus.
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Artificial intelligence (AI) is here to stay. It is not a future anymore, and there are many particular problems in cardiology that are already being solved via machine learning (ML), and many more are to come. ⋯ However, cardiologists who will not be able to use ML algorithms in their clinical practice will be replaced by those who will. (Fig. 2, Ref. 50). Keywords: artificial intelligence, cardiology, potential machine learning, survival models, classification algorithms, computer vision, automated analysis of various imaging examinations, ECG interpretation, phenotype clustering, pathophysiological mechanisms.
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No abstract Keywords.