Bratisl Med J
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Many of the deletions and large mutations found in the Omicron version of COVID-19 are identical to those seen in the α, π, β, and δ based VOCs. Such deletions and alterations have long been known to increase the viral risk of transmission and binding ability. Additionally, these changes are anticipated to increase the chances of immunological evasion and antibody secretion. ⋯ This review sheds insight on several genetic mutations and their evolution in distinct variations. However, further study is needed to improve our understanding of illness transmissibility, immune escape capacity, patient features and severity, and the use of further diagnostic and therapeutic techniques (Fig. 1, Ref. 20). Keywords: SARS-CoV-2, global vaccination, booster doses, COVID-19.
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To characterize the perinatal outcomes of pregnancies complicated by spontaneous previable premature rupture of membranes with a therapeutic intervention in the form of amniopatch (AP) at the 2nd Department of Obstetrics and Gynecology (2008‒2019). ⋯ Amniopatch can be a therapeutic method for reducing the neonatal mortality associated with RDS, maternal infectious morbidity, and an alternative in patients, who require an active approach to such a compromised pregnancy (Tab. 12, Fig. 1, Ref. 50).
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Medicinal plants exert therapeutic effects or have beneficial healing functions on the human or animal body. Medicinal plants are widely used in traditional medicine as an interesting alternative and/or complementary to science-based medicine. Compared to chemical drugs, medicinal plants have a lower risk of side effects, are eco-friendly, and have cost-effective production. ⋯ Respiratory and cardiovascular effects are also reported. In this review, we will analyze and characterize the known roles of VAC in mastalgia, as well as the mechanism of action reported in in vitro and/or in vivo studies, and show the potential for alternative therapeutic uses in mastalgia, also known as breast pain (Fig. 2, Ref. 40). Keywords: mastalgia, Vitex agnus-castus, therapy, traditional medicine.
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The repeated exposure of normal cells to carcinogenic agents may lead to mutations in their genetic material, changing them into cancerous cells. In this case, the structure and function of these cells would alter, and they would not behave like a normal cell. Treatment of cancer by bacteria is a promising and new strategy. ⋯ Besides describing H. pylori virulent factors and their role in cancer incidence, we also discuss how their potentials can significantly be strengthened and used for cancer treatment. This review results suggest that some factors of H. pylori can be exploited as therapeutic agents for cancer therapy in future (Tab. 1, Fig. 3, Ref. 77). Keywords: apoptosis induction, bacteriotherapy, cancer treatment, Helicobacter pylori.
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The aim of this cross-sectional study was to investigate the determinants of COVID-19 vaccine acceptance in University of Defence members. ⋯ To increase the vaccination rate it is necessary to target the younger population and increase awareness of vaccine safety and efficacy. If these measures are not sufficient to encourage voluntary vaccine acceptance, consideration should be given to making vaccination mandatory for selected professional groups (Tab. 5, Fig. 1, Ref. 25).