Bratisl Med J
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The study presents associations between prevalence of chronic diseases and selected socio-economic (SES) attributes in adult population of Slovakia and analyses the prevalence of chronic diseases in regions of Slovakia. ⋯ The study did not confirm a higher prevalence of chronic diseases in regions with weaker SES in Slovakia. Out of the 4 monitored SES attributes, 3 of them (age, education and lifestyle) had a significant impact on the prevalence of chronic diseases. Household income showed only a minimal association with the prevalence of chronic diseases, but this interdependence was not significant (Tab. 6, Ref. 41). Text in PDF www.elis.sk Keywords: socio-economic status, chronic diseases, age, household income, education.
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The COVID-19 pandemic has caused several negative changes. Increased alcohol consumption has been reported in some studies. This study aimed to compare the level of alcohol consumption among college students in the central and eastern regions of Slovakia. ⋯ Alcohol consumption is a significant problem in Slovakia. The number of students with a high AUDIT score from the eastern region is higher than the number of students with a high AUDIT score from the central region. More significant differences were found between men compared to women from eastern and central Slovakia (Tab. 5, Fig. 2, Ref. 34). Text in PDF www.elis.sk Keywords: alcohol consumption, AUDIT, pandemic, COVID-19, Slovakia.
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Case Reports
APOC3 and ABCA1 variants in unusual combined hypolipidaemia showing premature peripheral vascular disease.
Familial combined hypolipidaemia is a condition characterised by very low concentrations of circulating very-low-density lipoprotein (VLDL), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). It is thought that low LDL/combined hypolipidaemia can protect from cardiovascular disease (CVD), but this is not what we found in a case we present. ⋯ The heterogeneous nature and the risk of atherosclerosis in combined hypolipidaemia seems to be variable, based on an interplay between low HDL and LDL levels, and it depends on the combination of variants that cause it (Tab. 2, Ref. 38).
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Sepsis is the second most common cause of death in patients with non-cardiovascular diseases admitted to the ICU. It is one of the top ten reasons for death among all hospitalized patients. This study aimed to compare the value of some blood parameters in diagnosing sepsis and investigate their relationship to select a more practical diagnostic method. ⋯ Clinically, accurate detection of sepsis and predicting the patients at risk of developing sepsis is useful for improving treatment. Given the significant differences between HR, O2Sat, and SBP between normal and sepsis patients in this study, it may be possible to use these tests as simple tests instead of the complement protein 3 (C3) and Procalcitonin (PCT) tests to diagnose sepsis in the ICU (Tab. 8, Fig. 10, Ref. 39). Text in PDF www.elis.sk Keywords: sepsis, physiological parameters, detection; feature extraction, statistical analysis.
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Diabetes mellitus (DM) and altered glucose metabolism have been associated with carcinogenesis, but also with prognosis and tolerance to treatment in different types of cancer. Head and neck cancers (HNC), the sixth most common malignancy worldwide, require a multimodal approach, especially in advanced stages and cancer specific treatment is often associated with therapeutic failure and severe toxicities even if it is delivered according to current standards. The aim of the study was to evaluate the clinical, biological and outcomes implications of DM in patients with HNC. ⋯ A large percent of sinonasal cancers compared to the data reported in the literature could be also related to DM. Both this possible association and the benefit of Metformin and 5-Flurouracil must be reevaluated in studies in larger groups of patients (Ref. 25). Keywords: diabetes, head and neck cancers, metformin, toxicity, outcomes, chemotherapy.