Der Nervenarzt
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Review Case Reports
[Herpes zoster: follow-up, complications and therapy].
In clinical practice herpes zoster infections are common. The cause is the reactivation of the herpes varicella virus that persists in the sensory ganglia after an earlier primary infection with shingles. ⋯ A proposed reason for these complications is the direct infiltration of the virus or a hematogenous infection. Some of the complications can be treated symptomatically such as post-zoster neuralgia and the occurrence of certain complications that can be prevented by the right choice of acute therapy.
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Comparative Study
[Epidural cerebrospinal fluid pressure measurement and therapy of intracranial hypertension in "malignant" middle cerebral artery infarct].
A permanent elevation of ICP after severe brain injury for instance in subarachnoid or intracerebral hemorrhage or neurotrauma is associated with a poor clinical outcome. Although increasingly being used in the intensive care of patients with elevated ICP, continuous epidural ICP monitoring in ischemic stroke has not been firmly established yet. ⋯ We conclude that ICP monitoring in large hemispheric infarction may predict clinical outcome. ICP monitoring was not helpful in guiding long term treatment of ICP. It remains doubtful, whether ICP monitoring has a positive influence on clinical outcome of acute severe ischemic stroke.
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The "International Committee of Medical Journal Editors" has revised its guidelines regarding the protection of patients' rights to privacy in manuscripts submitted to biomedical journals. Information that might identify patients should not be published unless it is essential for scientific purposes and the patient has given written informed consent for publication after having been shown the manuscript to be published. This article discusses the new guidelines in the clinical context of psychiatry and psychotherapy. The ethical and legal problems raised concern (1) the informed consent process, (2) the content of scientific work and (3) the problem of third party consent (e.g. legal guardians).
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This article reviews the theoretical background, the sometimes severe side effects and the possible clinical implications of treatments with monoclonal anti-T cell antibodies in Multiple Sclerosis (MS). We conclude that there is no indication for treatment with monoclonal anti-T cell antibodies at the present time, except in controlled trials.