Chinese Med J Peking
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Chinese Med J Peking · Jul 2001
Protective effect of human CD40-Ig fusion protein in a murine model of acute graft-versus-host disease.
To investigate the protective effects of blocking CD40/CD40L interactions with human CD40-Ig fusion protein in a murine graft-versus-host disease model. ⋯ These results demonstrate that CD40/CD40L interactions play an important role in the pathogenesis of graft-versus-host disease and suggest clinical potential for CD40-Ig in the prevention and treatment of human graft-versus-host disease.