Chinese Med J Peking
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Chinese Med J Peking · Dec 1998
Single-strand conformation polymorphism for analysis of genomic variability of hepatitis C virus nonstructure 5A region.
To establish a convenient method to detect the genomic population with hepatitis C virus (HCV) at nonstructure 5A (NS5A) region and to determine the correlation between the genomic population complexity at NS5A region and disease stage. ⋯ These results suggest that the genomic variability of HCV at NS5A region increases with the progression of liver disease, and this may be closely related to the clinical features of type C liver disease.
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Chinese Med J Peking · Nov 1998
Extended frontotemporal epidural approach to cavernous sinus: surgical anatomy and technique.
To investigate the surgical technique of trans-frontotemporal extended epidural approach to the cavernous sinus. ⋯ The extended frontotemporal epidural surgical approach is superior to the routine intradural or combined epi- and intradural approaches. It is suitable for most of the cavernous sinus surgeries.
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Chinese Med J Peking · Nov 1998
Excitatory amino acids in cerebrospinal fluid and their relations with clinical features and outcomes in acute head injury.
To determine the contents and dynamics of excitatory amino acids (EAAs), glutamate (GLU) and aspartate (ASP) in the cerebrospinal fluid (CSF) of patients with acute head injury and to clarify the relationship of EAAs with clinical features and outcomes. ⋯ The content of EAAs in CSF increases following acute head injury and remains higher at least a week post-injury in severely injured patients. The more severe the trauma, the more obvious the excitotoxicity induced by EAAs; the more serious the secondary brain insult and the brain edema will be, the worse the outcome, naturally.
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Chinese Med J Peking · Oct 1998
Linkage analysis of the genetic markers of the candidate genes with non-insulin dependent diabetes mellitus in Chinese families.
To explore the relationship between the genetic markers of the candidate genes (insulin receptor, glucose transporter 2 and glucokinase) and non-insulin dependent diabetes mellitus (NIDDM) in Chinese pedigrees. ⋯ Mutations in or near the insulin receptor gene are unlikely to be the major cause of inherited predisposition to NIDDM in Chinese pedigrees that are related in this study, not excluding the principal role in the other Chinese or populations, while the mutations/variations near or at the glucose transporter 2 gene locus might be something of the cause, which needs more data to be ascertained, of familial NIDDM in Chinese pedigrees. However, the variations in or near the glucokinase gene might play a dominant role in the development of NIDDM in some Chinese and represent a subgroup of common NIDDM.