Dan Med Bull
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The primary aim of the haemostatic mechanism is to protect the vascular system and to keep it intact after injury in order to secure the function of tissues and organs. A second aim is to provide a matrix in wound healing and tissue repair. The regulation of this physiological mechanism is effected by a dynamic haemostatic balance comprising interactions between endothelial cells, thrombocytes, coagulation, and fibrinolysis. ⋯ Effects of disturbances in the balance are illustrated by description of cases of haemorrhagic disorders or thrombosis, and the pathophysiological aspects are surveyed. The regulation of coagulation and fibrinolysis follows in both systems the same pattern. The active enzymes (thrombin and plasmin, respectively) are formed by activation of circulating proenzymes, and inhibitors (circulating or localized) exert their modifying influences at various stages of the total process.(ABSTRACT TRUNCATED AT 400 WORDS)
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The utilisation of health services over a one-year period by an adult population of 38 probands with Down Syndrome (DS) (23 males 60.5% and 15 females 39.5%) in the Danish County of Aarhus (CA) was surveyed. All patients were born between 1 January 1934 and 31 December 1943, mean age 45.7 years. Prevalence: 0.056% on day of census: 31 December 1984. ⋯ Patients living in an institution with its own dental clinic do not see a dentist more often than patients getting their dental care from dentists in private practice. It is concluded that the present study states minimum figures and that adults with DS utilise health services more frequently than the background population. This is due to the findings of many additional diseases and handicaps among this aging group.