Dtsch Arztebl Int
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Editorial Comment
Rethinking the role of hydroxyethyl starch in fluid replacement.
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Editorial Comment
Mental health and psychological illness in adolescence.
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Review Meta Analysis
Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction.
The epidemiology of type 2 diabetes in Germany is of major societal interest, as is the question of the predictive value of genetic and acquired risk factors. ⋯ The prevalence of type 2 diabetes in Germany has risen in recent years. The discovery of new genetic variants that confer a higher risk of developing the disease has improved our understanding of insulin secretion in diabetes pathogenesis rather than the prediction of individual diabetes risk ("personalized medicine").
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Review
Malignant pleural mesothelioma: incidence, etiology, diagnosis, treatment, and occupational health.
The incidence of malignant mesothelioma in Germany is about 20 cases per million persons per year. Its association with asbestos exposure, usually occupational, has been unequivocally demonstrated. Even though the industrial use of asbestos was forbidden many years ago, new cases of mesothelioma continue to appear because of the long latency of the disease (median, 50 years). Its diagnosis and treatment still present a major challenge for ambulatory and in-hospital care and will do so for years to come. ⋯ The incidence of mesothelioma is not expected to drop in the next few years. The available treatments are chemotherapy, surgery, and radiotherapy. Specialized treatment centers now increasingly provide multimodal therapy for treatment of mesothelioma.