Gac Med Mex
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Observational Study
Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19.
One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome. ⋯ Age and vitamin D concentration were predictive factors for mortality in COVID-19-infected patients.
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Functional mitral regurgitation (FMR) is the result of three-dimensional structural disruption of the mitral valve due to left ventricular dysfunction. The "edge-to-edge" surgical technique has given rise to the percutaneous transcatheter edge-to-edge repair (TEER) technique to treat FMR; however, the lack of a mitral annuloplasty ring makes TEER only partially effective, with uncertain long-term results. The MITRA-FR and COAPT trials, on which current TEER recommendations are based, show conflicting results. COAPT results possible bias has influenced current recommendations issued by clinical practice guidelines in favor of TEER in FMR.
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In older adults, the association of frailty and sarcopenia with vitamin D deficiency is well known, but the association of the components of frailty syndrome has been poorly studied. ⋯ The frail and pre-frail phenotypes, as well as exhaustion, are associated with vitamin D insufficiency.
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There are aspects of COVID-19 pathogenesis that are still unknown. ⋯ SARS-CoV-2 VL determined at hospital admission might classify risk simultaneously with other factors described in COVID-19.
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Epigenetic and genomic imprinting alterations of the 11p15.5 region cause excessive or deficient growth, which result in Beckwith-Wiedemann syndrome (BWS) or Silver-Russell syndrome (SRS), respectively. ⋯ Adequate genotype-phenotype correlation was observed with the methylation defects that were identified, which confirms the usefulness of MLPA as a first-line study in patients diagnosed with BWS and SRS.