Gac Med Mex
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Surgery, radiotherapy or radiotherapy alone (RTA) constitute conventional treatment regimes for advanced stages of squamous cell carcinoma originating in the head and neck mucosa. Nevertheless, the results in advanced regional carcinoma (ARC) are disappointing. The chemotherapy-radiotherapy (CHT-RT) association has shown to be superior to RTA in irresectable disease and in resectable disease it could substitute initial surgery as a rescue alternative. ⋯ The GRT association offers a complete response rate of 60%; nevertheless morbidity was not insignificant; randomized studies with a larger number of patients will be required to allow us to outline the optimal therapeutic scheme.
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Randomized Controlled Trial
[Dexmedetomidine as preventive postoperative analgesia in inguinal hernioplasty].
Preemptive analgesia, is obtained via aspartate antagonists and glutamate, neurotransmitters released during tissular injury. Objective Asses preemptive analgesia with dexmedetomidine and consumption of a postanesthesia analgesic. ⋯ Intravenous dexmedetomidine administered prior to anesthesia decreases pain intensity and consumption of postoperative analgesia.
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Review Comparative Study
[Hepatic fibrosis: role of matrix metalloproteases and TGFbeta].
Liver fibrosis and cirrhosis involve multiple cellular and molecular events that lead to deposition of an excess of extracellular matrix proteins and increase the distortion of normal liver architecture. Etiologies include chronic viral hepatitis, alcohol abuse and drug toxicity. Degradation of these matrix proteins occurs predominantly as a result of a family of enzymes called metalloproteases (MMPs) that specifically degrade collagenous and non-collagenous substrates. ⋯ This molecule blocks the conversion of plasminogen into plasmin, and the MMP cannot be activated. At a second level, the inhibition is possible by binding to inhibitors called TIMP that can inhibit the proteolitic activity even when the MMPs had been previously activated by plasmin. During abnormal conditions, overexpression of these inhibitors is directed by the transforming growth factor-beta that in a fibrotic disease acts as an extremely important adverse factor.