Hippokratia
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Previous transcranial magnetic stimulation (TMS) studies in patients with tropical spastic paraparesis (TSP) have focused on central motor conduction time measurements while other TMS parameters remained unexplored. From a neuroradiological point of view, pyramidal tract involvement with magnetic resonance imaging and diffusion tensor imaging (DTI) has been rarely reported in TSP. Accordingly, the present study investigated the mean threshold (MT) and silent period (SP) as well as DTI measurements in TSP. ⋯ The described results provide novel neurophysiological and imaging evidence for central motor pathways malfunctioning in TSP. HIPPOKRATIA 2017, 21(4): 191-193.
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Varicose vein disease is one of the most common inherited disorders worldwide that causes mental, cosmetic, medical, and socio-economic problems. Varicose vein formation is thought to be multifactorial and often develops through the interaction of environmental and genetic risk factors. Its incidence displays a trend parallel to the distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism worldwide. The objective of this study was to determine the incidence of MTHFR C677T and A1298C mutations in Turkish patients with varicose veins. ⋯ Our findings display that the rates of MTHFR C677T and A1298C genotypes are similar between patients with varicose veins and healthy subjects in Turkish society. However, should FLV or PG G20210A polymorphisms accompany these polymorphisms, then there might be a tendency to development of superficial venous thrombosis. Further studies are required to support these findings. HIPPOKRATIA 2017, 21(4): 175-179.