Hippokratia
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Cutaneous diseases are observed with increasing duration and severity of renal disease in patients with chronic kidney disease (CKD). This study aimed to elucidate dermatological manifestations at different stages of CKD and determine their relationship with interleukin 31 (IL-31), a T-cell cytokine that induces severe pruritus, and uridine diphosphate (UDP)-glucose ceramide glucosyltransferase (UGCG), an enzyme that metabolizes ceramide, which plays an important role in moisturizing epidermis. ⋯ IL-31 might play a role in the development of longitudinal nail ridges, whereas UGCG might provide protection from pruritus and xerosis in patients with CKD. HIPPOKRATIA 2019, 23(2): 75-80.
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Case Reports
Percutaneous coronary intervention for distal coronary graft anastomosis le-sions: a case series.
Management of coronary artery graft failure, especially at the site of a recent distal anastomosis, is a challenging clinical situation, and literature data are scarce. ⋯ Percutaneous coronary intervention at distal graft anastomotic lesions is challenging, it can be performed from either the graft or the native vessel, and the angiographic result may not always be optimal. HIPPOKRATIA 2019, 23(2): 87-91.
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The non-communicating rudimentary horn of a unicornuate uterus is the rare result of abnormal development of the Müllerian ducts during embryogenesis. Case description: We report a rare condition of a pregnancy of eight weeks of gestation in a non-communicating rudimentary horn of a unicornuate uterus, which was diagnosed without specific symptoms and treated through laparoscopy. ⋯ Early diagnosis and treatment are essential to prevent the high maternal risk of life-threatening bleeding complications. HIPPOKRATIA 2019, 23(2): 92-94.
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Autophagy is an inducible intracellular process that has been studied mostly in cancer and less in inflammatory diseases. To establish the relation between cholecystitis (calculous and acalculous) and autophagy, we studied the expressions of immunohistochemical markers Beclin-1, LC3A, and Ki-67 in gallbladder epithelium and their significance in the induction of autophagy. ⋯ In the epithelium of calculous cholecystitis, overexpression of LC3A is related to Beclin-1 overexpression, which reinforces the view that Beclin-1 promotes autophagy in stone cholecystitis. HIPPOKRATIA 2019, 23(2): 64-69.
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Atherosclerosis of the large arteries of the neck could be related to the cognitive and motor deficit. We investigated if the atherosclerosis of common carotid and femoral arteries in patients with multiple sclerosis (MS) is directly linked with a disability and has an inverse relationship with cognitive performance. ⋯ Our results suggest that the degree of atherosclerosis, as calculated by the ATHUS score, is directly related to low cognitive score and higher sensory and motor disability. HIPPOKRATIA 2019, 23(2): 81-86.