J Postgrad Med
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Case Reports
Fulminant amebic colitis: An unusual postoperative complication of intraabdominal malignancy.
Amebiasis caused by protozoa Entamoeba histolytica (EH) is the third leading parasitic cause of human mortality. Although amebiasis is endemic in India, only about 10% of the infected individuals manifest disease. Clinical spectrum of amebiasis ranges from asymptomatic colonization to amebic colitis to hemorrhagic and fulminant colitis. ⋯ Host factors such as immunocompromised states may make an individual susceptible to develop symptomatic infection. Malignancies usually result in chronic debilitation which may make the individual prone to develop invasive amebiasis with rapid progression. We report two cases of invasive amebiasis which developed a fulminant course in the immediate postoperative period after abdominal surgeries for visceral malignancies.
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Aleatory uncertainties are generated by intrinsic factors such as studying a sample rather than the whole population and the source of epistemic uncertainties is extraneous such as limitations of knowledge. These uncertainties inflict all the findings in empirical medical research, but they are rarely appreciated. ⋯ We conclude that aleatory and epistemic uncertainties should get due consideration while drawing conclusions and before the results are put into practice. Methods to reduce their impact on results are also presented.
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Observational Study
The predictors of outcome and progression of pediatric sepsis and septic shock: A prospective observational study from western India.
There is a paucity of studies on the progression and outcome of Systemic Inflammatory Response Syndrome (SIRS) with its determinants. ⋯ SIRS can progress to septic shock if not identified early. The predictors of mortality were positive blood cultures, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and requirement of supportive care. The predictors of progression to septic shock were abnormal leukocyte count, culture positivity, and severe acute malnutrition.