Niger J Clin Pract
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Homozygous sickle cell patients are prone to renal damage which can be on-going in and out of crises, therefore, there is a need to monitor renal status using glomerular filtration rate. Equations to estimate GFR are readily available. Cockcroft-Gault equation is widely used, while the MDRD formula is the currently accepted equation. The CKD-EPI equation is recently being recommended but has not been validated among HbSS patients. Therefore, we aim to compare estimated GFR using CKD-EPI versus MDRD and Cockcroft-Gault equations among HbSS patients. ⋯ One hundred and twenty patients comprising 60 HbSS patients and 60 HbAA controls participated in the study. The HbSS patients had mean ± SD age of 26±6.7years, plasma creatinine 77 ± 17umol/L, eGFR: CG 93±31.6ml/min, MDRD 124 ± 34.8ml/min/1.73m2, CKD-EPI 122 ± 25.1ml/min/1.73m2 (pConclusion: CKD-EPI equation is best for individuals with GFR > 60ml/min/1.73m2. This study has shown that it correlates well with the currently acceptable MDRD equation, therefore, can be used to monitor the renal status of stable HbSS patients. CG gives poor correlation and bias with CKD-EPI. Further validation studies on CKD-EPI equation are needed in different patient populations.
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Raoultella ornithinolytica is an encapsulated gram-negative aerobic bacillus belonging to the Enterobacteriaceae family. It is one of the three species of Raoultella. Human infections related to R. ornithinolytica are exceedingly rare. This case report describes an ENT infection caused by R. ornithinolytica successfully treated with antibiotic therapy.