Niger J Clin Pract
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To study the role of hypoxia inducible factor-1α (HIF-1α) in patients with diabetic nephropathy (DN). ⋯ HIF-1α was up-regulated in DN patients, which might give clinical basis to the role of HIF-1α in the development of DN.
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Multicenter Study
Physical and socioeconomic impact of asthma in Nigeria: Experience of patients attending three tertiary hospitals.
Understanding the impact of asthma is the key to optimal care. ⋯ Asthma causes broad and substantial physical and socioeconomic impacts in our sample of patients. Exploring these impacts and engaging the patient is imperative for holistic management and good health outcomes.
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Repair of a failed amalgam or composite resin (CR) restoration has been extremely studied and proposed as a routine clinical treatment option; however, repair potential of glass ionomer-based restorative materials was not studied sufficiently in the literature. ⋯ Repair of restorative GH with CR appears as a preferred option to improve the bond strength.
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Comparative Study
Comparison of efficiency of hyaluronic acid and/or bone grafts in healing of bone defects.
Reconstruction of bone defects in oral and maxillofacial surgery has widespread uses. In recent years, the capacity of various biomaterials alone or in combination with bone graft materials to increase bone healing has been an intensive research topic. The aim of this study is to evaluate the efficacy of hyaluronic acid and/or bone graft material on bone healing in defects created in the rat mandible. Methods: In our study, rats were divided into 4 groups. Group 1 is designated to be treated with no materials, Group 2 with graft material, Group 3 with only hyaluronic acid, and Group with hyaluronic acid and graft material. A critical-size defect of 5 mm in diameter was created bilaterally in the rat mandibles and the rats were divided into the indicated groups accordingly. At the end of the postoperative 6th week, the experiment was terminated. The right halves of the mandibles were evaluated immunohistochemically and histopathologically in terms of bone healing, and the left in terms of mineralization level via microcomputed tomography. ⋯ In conclusion, the use of hyaluronic acid alone or in combination with bone grafting has been shown to contribute positively to the improvement of bone defects in the jaw area.
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Randomized Controlled Trial Comparative Study
Comparative analgesic efficacy and tolerability of celecoxib and tramadol on postoperative pain after mandibular third molar extraction: A double blind randomized controlled trial.
The choice of an efficacious and well-tolerated analgesic for the control of postoperative pain after third molar surgical extraction remains a challenge. ⋯ In our study, celecoxib was more efficacious and better tolerated than tramadol for the management of pain after surgical extraction of mandibular third molar.