Pak J Med Sci
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To determine the frequency of mutations in Low density lipoprotein receptor gene at exon 2 and 4 and its association with premature coronary artery disease (PCAD). ⋯ Glutamic acid (E) is replaced by Lysine (K) at position number 207 (E207K) mutation at exon 4 of low-density lipoprotein receptor (LDLR) gene may be the causative genetic basis of premature coronary artery disease among Pakistani population. The identified synonymous mutation at exon 2 was not causative as there is no change in the amino acid.
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To evaluate the effect of oral progesterone for the treatment of abnormal uterine bleeding in patients taking warfarin after prosthetic valve replacement. ⋯ The warfarin induced abnormal uterine bleeding can be controlled effectively and safely with low dose of oral progesterone.
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Autism spectrum disorder (ASD) is complex neurodevelopmental condition described by impairments in three main behavioral areas: social deficits, impaired communication, and repetitive behaviors. Despite many years of vast study, the causes of ASD are still unknown. ⋯ The literature search was done using PubMed and Google Scholar databases up to October 2018. Key words "Environmental Pollution", "Nutritional Factors", "Diabetes Mellitus", "Autism Spectrum Disorder" were selected.
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This descriptive cross-sectional study was carried out to investigate the relationship between fatigue, and sleep quality, pain and depression in patients with knee osteoarthritis. ⋯ The participants with knee osteoarthritis suffered fatigue more than did the healthy participants. This fatigue suffered by them affected their sleep quality, pain and depression negatively.
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To analyze the contents and format of peer review proforma of Medical journals of Pakistan. ⋯ A spectrum of contents and format of peer review proformas of medical journals were observed. We found structured peer review proforma with a scoring scale comprehensive and more appropriate for peer review.