Pak J Med Sci
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Accurately identifying the cellular, biomolecular, and toxicological functions of anticancer drugs help to decipher the potential risk of genotoxicity and other side effects. Here, we examined bleomycin for cellular, molecular and toxicological mechanisms using next-generation knowledge discovery (NGKD) tools. ⋯ Analysis of TGx-DDI data of bleomycin using NGKD tools provided information about toxicogenomics and other mechanisms. Integration of all "omics" based approaches is crucial for the development of translatable biomarkers for evaluating anticancer drugs for safety and efficacy.
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COVID-19 vaccine has become available within a record time but mere availability will not control the pandemic. High vaccine acceptance is required. The objective was to determine COVID-19 vaccine acceptance and its associated factors among Pakistani population. ⋯ Gender and marital status was significantly associated with vaccine acceptance. Forty-six percent respondents were willing to take the vaccine. Among the vaccine hesitant group, respondents were worried about the side effects, safety and religious permissibility of vaccine. Policy makers and all the relevant stakeholders should consider low vaccine acceptance as a major bottleneck and should devise strategies to address this major issue in the fight against COVID-19.
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To investigate the correlation between systemic immune inflammatory (SII) index, serum interleukin-35 (IL-35) and high mobility Group-Box one (HMGB-1) with the severity and prognosis of sepsis. ⋯ SII, IL-35 and HMGB-1 are remarkably correlated with the severity and prognosis of patients with sepsis. With the increasing in SII, IL-35 and HMGB-1 levels, patients will suffer from severe disease progression and poor prognosis, which require more clinical attention.
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To determine the frequency of clinical anger, adverse childhood experiences, self-esteem, and their mutual relationship among undergraduate medical and sociology students. ⋯ The high frequency of clinical anger necessitates the implementation of periodic screening across all universities. Keeping in mind the problem of low self-esteem and the history of ACEs, there is an urgent need for the development of strategies to preserve and improve the mental well-being of the young generation.
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The aim of our study was to evaluate the effect of tear and repair of the lateral meniscal posterior root (LMPR) on the patellofemoral contact pressure of the knee after anterior cruciate ligament (ACL) reconstructed. ⋯ The posterior root tear and repair of the lateral meniscus could have an influence on patellofemoral contact stress of the knee after ACL reconstruction at 30° of knee flexion.