Presse Med
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UNCOMMON MALIGNANCY: Adrenocortical carcinoma is a very rare malignancy with poor prognosis. Median survival ranges from 12 to 25 months. Most clinicians recommend aggressive surgical management of either local or recurrent and metastatic disease. ANTICORTISOL AGENTS: Mitotane, the most tested agent against inoperable and metastatic adrenocortical carcinoma, procures overall response rates of 20 to 25%, but recent data do not support its use in the adjuvant setting.
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HIGH PREVALENCE: Hypertension is observed in 85% of patients with end-stage renal disease. Its prevalence is also very high in renal transplant recipients.
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FREQUENT: The most frequent deep localization, endometriosis of the rectovaginal septum may penetrate into the vagina or rectum.
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LEPTINE: Produced by adipose tissue, leptine is a regulatory hormone controlling body fat mass.